Dr Julie Gough

Julie graduated from the University of Wales, Aberystwyth in 1993 with a BSc in Cell and Immunobiology and then gained an MSc from Leicester University in 1994 in Molecular Pathology and Toxicology. In 1999 Julie was awarded a PhD in biomaterials from the University of Nottingham and continued at Nottingham as a postdoctoral research associate working on novel composites for craniofacial bone repair. Prior to her appointment in 2002 at the Materials Science Centre, Julie was a PDRA at Imperial College London investigating bone formation on bioactive glass scaffolds.

Julie's focus of research over the last 15 years has been the cell/biomaterial interface. Her research in Manchester focuses on tissue engineering of mechanically sensitive connective tissues such as bone, cartilage, intervertebral disc, skin and skeletal muscle. Controlling specific cell responses by using defined (in terms of chemistry and topography) surfaces is also a focus of research.

• Tissue engineering of the intervertebral disc
• Fibrous cellulose scaffolds for tissue engineering
• Self-assembled peptide scaffolds for cartilage and skin tissue engineering
• Responsive surfaces to control cell adhesion
• Bioactive glass/polymer composites for hard tissue replacement
• Novel alloys for bone repair
• Controlling cell shape

• Dugan J, Gough JE, Eichhorn SJ. Directing the morphology and differentiation of skeletal muscle cells using oriented cellulose nanowhiskers. Biomacromolecules 2010;11(9):2498-2504
• Kalaskar DM, Ulijn RV, Gough JE, Alexander MR, Scurr DJ, Sampson WW, Eichhorn SJ. Characterisation of Amino Acid Modified Cellulose Surfaces using ToF-SIMS and XPS. Cellulose 2010, 17:747-756
• Aviss KJ, Gough JE, Downes S. Aligned electrospun polymer fibres for skeletal muscle regeneration. European Cells and Materials 2010;19:193-204
• Leng F, Gough JE, Webb SJ. Enhancing cell culture in magnetic vesicle gels. Materials Research Society Symposia Proceedings 2010, 1272, 1272-PP07-02
• Whiteside P, Matykina E, Gough JE, Skeldon P, Thompson GE. In vitro evaluation of cell proliferation and collagen synthesis on titanium following plasma electrolytic oxidation. Journal of Biomedical Materials Research Part A 2010;94A(1):38-46
• Todd SJ, Scurr DJ, Gough JE, Alexander MR, Ulijn RV. Enzyme-activated RGD ligands on functionalised PEG monolayers: surface analysis and cellular response. Langmuir, 2009;25(13):7533-7539
• Jayawarna V, Richardson SM, Hirst A, Hodson NW, Saiani A, Gough JE, Ulijn RV. Introducing chemical functionality in Fmoc-peptide gels for cell culture. Acta Biomaterialia, 2009;5(3):934-943
• Zhou M, Smith AM, Das AK, Hodson NW, Collins RF, Ulijn RV, Gough JE. Self-assembled peptide-based hydrogels as scaffolds for anchorage dependent cells. Biomaterials, 2009;30:2523-2530
• Kalaskar DM, Gough JE, Ulijn RV, Sampson WW, Scurr DJ, Rutten FJ, Alexander MR, Merry CLR, EichhornSJ. Controlling cell morphology on amino acid modified cellulose. Soft Matter, 2008;4:1059-1065
• Yan H, Nykanen A, Ruokolainen J, Farrar D, Gough JE, Saiani A, Miller AF. Thermo-Reversible Protein Fibrillar Hydrogels as Cell Scaffolds. Faraday Discussions, 2008;139:71-84
• Helen W, Gough JE. Cell viability, proliferation and extracellular matrix production of human annulus fibrosus cells cultured within PDLLA/Bioglass(R) composite foam scaffolds in vitro. Acta Biomaterialia, 2008;4:230-243
• Todd SJ, Farrar D, Gough JE, Ulijn RV. Enzyme-triggered cell attachment to hydrogel surfaces. Soft Matter, 2007;3(5):547-550
• Helen W, Gough JE. Three-dimensional culture of annulus fibrosus cells within PDLLA/Bioglass composite foam scaffolds: Assessment of cell attachment, proliferation and extracellular matrix production. Biomaterials, 2007;28(11):2010-2020
• Gough JE, Clupper DC, Hench LL. Osteoblast responses to tape cast and sintered bioactive glass ceramics. Journal of Biomedical Materials Research 2004;69(4):621-628
• Gough JE, Notingher I, Clupper DC, Hench LL. Osteoblast attachment and mineralised nodule formation on rough and smooth 45S5 bioglass monoliths. Journal of Biomedical Materials Research 2004;68A(4): 640-650
• Gough JE, Jones JR, Hench LL. Nodule formation and mineralisation of human primary osteoblasts cultured on a porous bioactive glass scaffold. Biomaterials 2003;25(11):2039-2046

http://personalpages.manchester.ac.uk/staff/j.gough/