Dr Sarah Cartmell

Sarah was appointed Reader in Biomaterials at The University of Manchester in September 2010 in the School of Materials. She received a B.Eng. in Materials Science with Clinical Engineering and a Ph.D. degree in Clinical Engineering from The University of Liverpool in 1996 and 2000 respectively and then furthered her studies at GeorgiaTech, Atlanta for two years as a postdoctoral research fellow. She joined Keele University in 2002 where she continued her postdoctoral studies until obtaining a Lecturer and then Senior Lecturer position in orthopaedic tissue engineering (2008 - 2010).

Sarah's research interests lie in orthopaedic tissue engineering with a focus on biomaterials characterisation, mechanotransduction, statins and bioreactor design.

• Influence of mechanical force application on human mesenchymal stem cell differentiation
• Design of a novel co-culture bioreactor for osteochondral tissue-engineered plugs
• Use of statins for influencing osteoblast proliferation and differentiation
• Validation of fluid flow characteristics in a Perfusion Bioreactor (for Bone Tissue Growth and cell seeding optimisation)
• Use of electrical stimulating regimes to influence stem cell proliferation and differentiation for tissue engineering purposes
• Ligament tissue engineering

• GLOSSOP, J.R. and CARTMELL, S.H. (2010) Tensile strain and magnetic nanoparticle force application do not induce MAP3K8 and IL1B differential gene expression in a similar manner to fluid flow in human mesenchymal stem cells, J. Tissue Engineering and Regenerative Medicine in press
• WANG, Q.G., HUGHES, N., CARTMELL, S. and KUIPER, N. (2010) The composition of hydrogels for cartilage tissue engineering can influence glycosaminoglycan profiles, e Cells and Materials Journal 19 pp.86-95
• L. ARAIDA HIDALGO-BASTIDA, L.A. and CARTMELL, S.H. (2010) Mesenchymal Stem Cells (MSCs) And Extracellular Matrix (ECM) Proteins: Enhancing Cell Adhesion And Differentiation For Bone Tissue Engineering Tissue Engineering Part B Rev 16(4) pp.405-412
• EL HAJ, A.J. and CARTMELL, S.H. (2010) Bioreactors for Bone Tissue Engineering, Special Issue of Proceedings of the Institution of Mechanical Engineers Part H: Engineering in Medicine in press
• KUMAR, D., GITTINGS, J., TURNER, I., BOWEN, C., BASTIDA-HIDALGO, A. and CARTMELL, S. (2010) Polarization Of Hydroxyapatite; Influence On Osteoblast Cell Proliferation Acta Biomaterialia 6(4) pp.1549-1554
• JONES, G.L, WALTON, R., CZERNUSZKA, J., GRIFFITHS, S.L., EL HAJ, A.J. and CARTMELL, S.H. (2010) Primary human osteoblast culture on 3D porous collagen-hydroxyapatite scaffolds, Journal of Biomedical Materials Research Part A 94(4) pp.1244-1250
• KIRKHAM, G.R., ELLIOT, K.J., KERAMANE, A., SALTER, D.M., DOBSON, J., EL HAJ, A.J., CARTMELL, S.H. (2010) Hyperpolarisation of Human Mesenchymal Stem Cells in Response to Magnetic Force IEEE Transactions of Nanobioscience 9(1) 71-74
• RATHBONE, S., FURRER, P., LUBBEN, J., ZINN, M. and CARTMELL, S. (2010) Biocompatibility of polyhydroxyalkanoate as a potential material for ligament and tendon scaffold material Journal of Biomedical Materials Part A 93(4) pp.1391-1403
• GLOSSOP, J.R. and CARTMELL, S.H. (2009) Differential gene expression of integrins alpha 2 and beta 8 in human mesenchymal stem cells exposed to fluid flow, Cellular and Molecular Bioengineering 2(4) pp. 554-553
• JONES, G.L., MOTTA, A., MARSHALL, M., J. EL HAJ A. J. AND CARTMELL, S. H. (2009) Osteoblast:osteoclast co-cultures on silk fibroin, chitosan and PLLA films, Biomaterials 30(29) pp.5376-5384.
• GITTINGS, J.P., BOWEN, C.R., DENT, A., TURNER, I.G., BAXTER, F.R., CARTMELL, S. and CHAUDHURI, J. (2009) Influence of Porosity on Polarisation and Electrical Properties of Hydroxyapatite Based Ceramics Ferroelectrics in press (available on-line ahead of print doi:10.1016/j.actbio.2009.11.008)
• CARTMELL, S.H. (2009) Controlled Release Scaffolds for Bone Tissue Engineering, Journal of Pharmaceutical Science Feb 98(2) pp. 430-41.
• WHITTAKER, R., BOOTH, R., DYSON, R., BAILEY, C., PARSONS CHINI, L., NAIRE, S., PAYVANDI, S., RONG, Z., WOOLLARD, H., CUMMINGS, L., WATERS, S., MAWASSE, L., CHAUDHURI, J., ELLIS, M., MICHAEL, V., KUIPER, N., CARTMELL, S. (2009) Mathematical modelling of fibre-enhanced perfusion inside a tissue-engineering bioreactor Journal of Theoretical Biology 256 pp. 533-546
• GLOSSOP, J. AND CARTMELL, S.H. (2009) Effect of fluid flow-induced shear stress on human mesenchymal stem cells: differential gene expression of IL1B and MAP3K8 in MAPK signaling Gene Expression Patterns Jun;9(5) pp.381-8
• PISKIN, E., ISOGLU, E., BÖLGEN, N., VARGEL, I., GRIFFITHS, S., ÇAVUSOGLU, T., KORKUSUZ, P., GÜZEL, E., CARTMELL, S. (2009) In vivo Performance of Simvastatin Loaded Electrospun Spiral-Wounded Polycaprolactone Scaffolds in Reconstruction of Cranial Bone Defects in the Rat Model Journal of Biomedical Materials Research: Part A 15;90(4) pp.1137-51
• GRIFFITHS, S.L. and CARTMELL, S.H. (2008) Use of Statins for Enhancing Bone Tissue Engineered Grafts, European Journal of Plastic Surgery, pp. in press (DOI 10.1007/s00238-007-0190-2).

http://personalpages.manchester.ac.uk/staff/sarah.cartmell/